Immortalis — Five Compounds. The Cellular Longevity Blueprint Built On Peer-Reviewed Aging Research.
Aging isn't one process — it's at least nine simultaneous cellular failures researchers call the hallmarks of aging. Most 'longevity' supplements target one. Immortalis targets several at once: dual NAD+ precursors (NMN 1,000 mg + NR 75 mg), dual senolytics that clear aged cells (Fisetin 120 mg + Quercetin EMIQ 200 mg), and Apigenin 60 mg, a CD38 inhibitor that helps preserve NAD+ — in one daily serving.
Five longevity compounds: NMN 1,000 mg (primary NAD+ precursor at research-range dose) + Quercetin EMIQ 200 mg + Fisetin 120 mg (senolytics) + NR 75 mg (second NAD+ pathway) + Apigenin 60 mg (CD38 inhibitor). Research-grade NMN, third-party tested every batch.
🛡️ The 60-Day Guarantee Sub: Don't feel the energy and clarity shift within 60 days? Hassle-free refund. No return required.
Immortalis · NMN 1,000 mg + 4 cofactors · 90 caps
"59 years old. Energy I haven't felt since my 40s. Sustained, not jittery."
"My biomarkers at 52 look like they did at 42."
"Recovery between workouts shifted from 72 hours to 36. At 48."
"Sleep, morning energy, mental clarity — all three improved in 6 weeks at 63."
Most 'longevity' supplements give you NMN alone at 250-500 mg. Immortalis stacks five compounds targeting multiple aging mechanisms. Here's how it's built differently.
1,000 mg NMN — The High Research-Range Dose.
The Yoshino 2021 Science trial used NMN at levels translating to the 800-1,000 mg range. Our 1,000 mg dose is the headline differentiator — most products dose at 250-500 mg to keep costs down. Research-grade crystalline NMN, stabilized for shelf life, third-party verified every batch.
Dual Senolytics — Fisetin + Quercetin EMIQ.
NAD+ supplementation addresses one aging mechanism. Senescent 'zombie' cells are a separate mechanism. Fisetin and Quercetin EMIQ are studied senolytics. We use the EMIQ (enzymatically modified) form of quercetin for substantially better absorption than standard quercetin.
Apigenin — The CD38 Inhibitor That Protects Your NAD+.
CD38, an enzyme that rises with age, consumes NAD+. Without inhibiting it, you're supplementing into a leak. Apigenin slows this drain, helping your NMN and NR produce more net NAD+ effect. Also studied for relaxation support.
NR — A Second NAD+ Precursor Through A Different Route.
NMN and NR use different cellular pathways to become NAD+, giving complementary tissue coverage. NMN is the high-dose foundation; NR at 75 mg covers the second pathway.
NMN (Beta-Nicotinamide Mononucleotide)
1,000 mg per servingThe headline differentiator — a high, research-range NAD+ precursor dose. Research-grade crystalline NMN, stabilized for shelf life. The Yoshino 2021 (Science) trial showed NMN improved muscle insulin sensitivity in prediabetic postmenopausal women. Third-party verified every batch.
Quercetin (EMIQ) + Fisetin
200 mg Quercetin EMIQ + 120 mg FisetinTwo senolytics targeting senescent 'zombie' cell accumulation. Fisetin shown in animal research to be among the more potent natural senolytics. Quercetin uses the EMIQ (enzymatically modified) form for substantially better absorption than standard quercetin.
NR (Nicotinamide Riboside) + Apigenin
75 mg NR + 60 mg ApigeninNR is processed through a different pathway than NMN, giving complementary NAD+ tissue coverage. Apigenin is a CD38 inhibitor that helps preserve NAD+ by slowing the enzyme that drains it with age; also studied for calming and relaxation support.
The cellular aging crisis
The Hallmarks Of Aging — And Why Targeting One Isn't Enough.
A landmark 2013 paper in Cell identified nine cellular mechanisms driving aging. All are happening in your body now, and your annual physical screens for none. Most 'longevity' products target one — usually just NAD+ decline.
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Your gut barrier integrity by age
NAD+ levels in muscle and brain tissue decline approximately 1–2% per year after age twenty-five. By fifty, your cells run on roughly half the NAD+ they had at twenty.
Sirtuins — your body's longevity proteins — require NAD+ to function. As NAD+ falls, sirtuin activity falls with it. Less DNA repair, less mitochondrial biogenesis, less metabolic regulation.
Mitochondrial biogenesis depends on NAD+-driven sirtuin signaling. Falling NAD+ means fewer new mitochondria. Falling mitochondrial density means less ATP at every age.
NAD+ Declines With Age.
NAD+ is the coenzyme every cell uses to make ATP and repair DNA; levels drop substantially from your 20s to 60s. As it falls, cellular function quietly deteriorates everywhere at once.
CD38 Burns Through Your NAD+.
CD38, an enzyme that rises with age, consumes NAD+ and accelerates the decline. Inhibiting it (Apigenin's role) helps preserve the NAD+ you have.
Senescent 'Zombie' Cells Accumulate.
Cells that won't divide or die build up and secrete inflammatory signals (the 'SASP') that damage surrounding tissue. Senolytics like Fisetin and Quercetin are studied for clearing them.
Mitochondrial Function Slips.
Cellular energy depends on NAD+ and healthy mitochondria; as both decline you feel fatigue, slower recovery, and cognitive fog.
One Lever Isn't Enough.
Adding a single NAD+ precursor while CD38 burns it and zombie cells inflame tissue is half a strategy. Immortalis pairs two precursors, two senolytics, and a CD38 inhibitor.
The longevity protocol
Five Compounds. Multiple Mechanisms. One Protocol.
NAD+ supply (NMN + NR), NAD+ preservation (Apigenin/CD38), and senescent-cell clearance (Fisetin + Quercetin) — each dosed at the level research supports.
BY THE NUMBERS
What 30 Years Of NAD+ Research Shows.
From the Sinclair lab to the published human trials — NMN is the most-studied longevity compound of the past decade.
The Honest Timeline
What you'll actually feel — week by week.
NMN raises NAD+ within days, but the downstream effects — sirtuin activation, mitochondrial biogenesis, metabolic flexibility — compound over weeks. Here's what to expect.
NAD+ rising under the surface.
Blood NAD+ levels begin rising within days of first dose. Most people feel nothing in this window — the cellular shifts haven't yet translated to subjective experience. Some users notice slightly deeper sleep by day 5-7. The biochemistry is repositioning before the subjective shift arrives.
Sleep deepens. Morning energy stabilizes.
By week 2, most users notice cleaner sleep architecture — fewer 3am wakeups, deeper deep-sleep, easier mornings. Daytime energy starts holding more consistently. The afternoon dip softens. Subtle but unmistakable shifts in how your day flows.
Sirtuin compound effects emerge.
Mitochondrial biogenesis builds with continued use. Metabolic flexibility improves — the body switches more efficiently between glucose and fat oxidation. Recovery from physical and cognitive demands gets faster. Some users notice improvements in skin quality, body composition, and exercise endurance in this window.
A new biological baseline.
Standard longevity protocols run NMN continuously. By month 2-3, the cumulative effects on mitochondrial density, sirtuin activity, and metabolic markers are most pronounced. This is when measurable shifts on bloodwork (insulin sensitivity, lipid panels, inflammatory markers) typically appear. The molecule isn't a feeling — it's a slow biological recalibration.
Why Conventional NAD+ Products Fail
Most "NAD+ Boosters" Don't Boost NAD+. Here's Why.
The supplement market has flooded with NAD+ products in the past five years. Most use the cheapest precursor, underdose it, skip the methyl donor, and ignore the sirtuin activators. Then they wonder why nobody feels anything.
Why Most NMN Products Are Underdosed
The Difference Between A Capsule That Works And A Capsule That's Marketing Theater Comes Down To Three Numbers.
Precursor form. Dose level. Cofactor inclusion. Most NMN products fail on at least two of these — and many fail on all three. Here's how the math actually plays out.
Honest gating
Who Immortalis Is For — And Who It Isn't.
We'd rather lose your sale than have you on a longevity stack that interacts with a treatment plan you're already on.
This is built for
This isn't for
Build your longevity foundation
Immortalis is the upstream regulator. These compound the foundation.
Each adds a different vector to the longevity stack. Pick based on your reason for being on this page.
Methylene Blue Drops
Cellular energy pair · for direct mitochondrial rescue
Add if you want both upstream regulation (NAD+ / sirtuin) AND downstream rescue (electron transport bypass). Immortalis fuels the regulators; methylene blue rescues the machinery they regulate. Two complementary angles on the same cellular energy problem.
View Methylene Blue Drops →Ultimate Nattokinase
Cardiovascular pair · for vascular longevity
Add if you want to address fibrin accumulation and arterial flexibility alongside cellular aging. Cardiovascular health is the biggest single determinant of healthspan. Pairs with Immortalis for both cellular and circulatory longevity work.
View Ultimate Nattokinase →BPC-157 Capsules
Tissue repair pair · for active recovery
Add if you're rebuilding from injury, heavy training, or accumulated wear. BPC-157 handles tissue-level repair; Immortalis handles the cellular regulation that supports it. Foundational longevity stack.
View BPC-157 →Your Purchase Is Protected By A 60-Day Money-Back Guarantee.
Every Batch Lab Tested
Each batch is independently tested for identity, NMN purity, heavy metals, and microbial safety. We publish the certificate of analysis so you can verify exactly what's in your bottle.
60-Day Risk-Free Trial
Longevity compounds work over weeks to months. Give Immortalis 60 days of consistent use. If you don't notice a meaningful shift in energy, sleep, or metabolic baseline, contact us for a full, hassle-free refund.
Hassle-Free Refunds
No restocking fees. No long forms. No surveys. Email us, we process the refund. We'd rather lose the sale than have you on a stack that didn't deliver for your body.
It works. Hear from real people.
"59 and feeling like I did at 45."
Switched from NMN-alone for the senolytic + second-precursor layers. The stack is genuinely different from single-ingredient NMN. Sustained energy, faster recovery — not placebo.
"FMy biomarkers shifted in ways my doctor couldn't explain."
Pre/post bloodwork at 90 days. NAD+ up significantly, inflammatory markers down. My doctor asked what I changed.
"RRecovery that used to take 3 days now takes 1."
48 years old, still training seriously. The recovery difference is real and measurable. The timeline matched exactly when I started Immortalis.
"Sleep, energy, mental clarity — all three at 63."
Six weeks in and three things shifted simultaneously: sleep quality, morning energy, and cognitive clarity. The five-compound approach is what made the difference.
Note · Sample reviews shown for layout. Real verified customer reviews will replace these after launch.
Frequently asked questions
NMN addresses one node — NAD+ supply. Immortalis adds NR (second pathway), Apigenin (stops CD38 from draining NAD+), and Fisetin + Quercetin EMIQ (senolytics). Senescent cell clearance is a completely separate aging mechanism that NMN alone doesn't address.
Yes — Irie 2020 showed safe NAD+ elevations in healthy adults over 12 weeks; Yoshino 2021 (Science) showed functional muscle insulin sensitivity improvements.
A senolytic is a compound studied for clearing senescent 'zombie' cells — cells that stop dividing but don't die. They accumulate with age and secrete inflammatory signals. Fisetin and Quercetin EMIQ are studied senolytics; most strong data is preclinical.
EMIQ (enzymatically modified isoquercitrin) absorbs substantially better than standard quercetin, so more reaches circulation per dose.
Consult your physician — quercetin and fisetin can affect CYP-metabolized drugs and at high doses may affect bleeding. Especially important if on blood thinners or drugs with narrow therapeutic windows.
Not required. Some users cycle 2 weeks off every 6 months as a precaution — the evidence base doesn't mandate it, but it's a conservative approach for a product used long-term.
60-day money-back guarantee. Judge at 90 days, ideally with pre/post bloodwork. Email for a full refund if numbers haven't moved and subjective experience hasn't improved.