Immortalis — The Cellular Energy Formula That Restocks The Master Molecule Your Body Stops Making At 30.
NAD+ is the most important molecule you've never heard of — a coenzyme present in every cell of your body, required for energy production, DNA repair, and the longevity proteins called sirtuins. By age 50, you have roughly half the NAD+ you had at 20. That single decline is upstream of nearly every age-related symptom: lower energy, slower repair, declining metabolic flexibility, foggier thinking. Immortalis is built around the most clinically-validated NAD+ precursor — and the supporting compounds your body actually needs to use it.
Our 500 mg clinical-grade NMN matches the dose used in the Yoshino 2021 Science study that improved muscle insulin sensitivity in prediabetic postmenopausal women — paired with resveratrol, pterostilbene, and TMG so your body can actually convert it.
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Immortalis · NMN 500 mg + 3 cofactors · 60 capsules
"Three weeks in and my deep sleep is up 40 minutes a night. My body feels different on the same hours."
"Recovery between training sessions cut in half. I'm 58, lifting like I did at 38."
"My fasting glucose dropped 12 points in six weeks. My endocrinologist asked what changed."
"First supplement that made my Whoop scores actually move. HRV up, resting heart rate down."
Most colostrum products use late-milking, mass-produced powder with degraded growth factors. Here's how Daily Colostrum is built differently.
NMN — Not NR. Not Niacin. Not Nicotinamide.
Most "NAD+ boosters" use cheap nicotinamide or niacinamide as the precursor. Both are valid biochemically, but the human clinical trial data sits with NMN (nicotinamide mononucleotide). The 2021 Yoshino study published in Science used NMN — not NR. We use what the published research used.
500 mg NMN — The Clinical Trial Dose.
Most NMN supplements come in 100-250 mg doses — half or less of what the published human trials have used. The Yoshino 2021 trial dosed at 250 mg in postmenopausal women; later studies have explored 500-1000 mg ranges. We dose at 500 mg because that's where the published metabolic effects actually emerge.
TMG Included — Because NMN Burns Methyl Groups.
What most NMN brands don't tell you: NMN metabolism consumes methyl groups in the body. Without supplemental methyl donors, long-term NMN supplementation can deplete methylation reserves and elevate homocysteine. We include 500 mg of TMG (trimethylglycine) per serving to keep methylation balanced. It's the safety net most products skip.
Resveratrol + Pterostilbene Activate The Sirtuins NMN Fuels.
NMN raises NAD+. But NAD+ is only useful if you actually activate the sirtuin proteins it powers. Resveratrol and pterostilbene (resveratrol's more bioavailable cousin) are the most-studied SIRT1 activators — and they work synergistically when given alongside NAD+ precursors. Without them, you raise the substrate without engaging the engine.
NMN (β-Nicotinamide Mononucleotide)
500 mg per servingThe direct precursor to NAD+ — your body converts NMN to NAD+ in a single enzymatic step. This is the form used in the Yoshino 2021 Science study that improved muscle insulin sensitivity in prediabetic postmenopausal women. It's the cleanest-data precursor available, with the most published human trials supporting metabolic and cellular energy outcomes.
The Synergy Stack: Resveratrol + Pterostilbene + TMG
200 mg + 50 mg + 500 mgResveratrol (200 mg, micronized for bioavailability) and pterostilbene (50 mg, resveratrol's more stable methylated cousin) are the most clinically-studied SIRT1 activators. TMG (500 mg) replenishes the methyl groups that NMN metabolism consumes — preventing the homocysteine elevation that plain-NMN protocols can produce over time. These three are why Immortalis works as a system, not a single ingredient.
The NAD+ Decline Crisis
Why You Run Out Of Energy By 40 — And No Amount Of Sleep Fixes It.
NAD+ is the master coenzyme your cells use for energy production and DNA repair. It declines roughly 50% between your twenties and your fifties. By 60, levels are 70-80% below baseline. Every age-related symptom — slower recovery, foggy thinking, slower metabolism, declining endurance — traces back to this single molecule running low. NAD+ doesn't decline because you're aging. You age because NAD+ declines.
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Your gut barrier integrity by age
NAD+ levels in muscle and brain tissue decline approximately 1–2% per year after age twenty-five. By fifty, your cells run on roughly half the NAD+ they had at twenty.
Sirtuins — your body's longevity proteins — require NAD+ to function. As NAD+ falls, sirtuin activity falls with it. Less DNA repair, less mitochondrial biogenesis, less metabolic regulation.
Mitochondrial biogenesis depends on NAD+-driven sirtuin signaling. Falling NAD+ means fewer new mitochondria. Falling mitochondrial density means less ATP at every age.
NAD+ Synthesis Slows After 25.
Your cells make NAD+ from precursors throughout life — but the rate-limiting enzyme NAMPT slows by roughly 30% per decade after twenty-five. Production drops while demand stays constant. The shortfall is small at first. By forty it's the dominant constraint on your cellular energy.
CD38 Eats More NAD+ As You Age.
CD38 is an enzyme that breaks down NAD+ — and its activity quadruples between your twenties and your sixties. So NAD+ is being made slower AND destroyed faster. The combined effect is a steeper decline than either factor alone would predict.
Sirtuins Go Dormant Without NAD+.
Your seven sirtuin proteins require NAD+ as fuel. When NAD+ runs low, sirtuins go quiet. SIRT1 stops repairing DNA. SIRT3 stops protecting your mitochondria. SIRT6 stops regulating glucose metabolism. These aren't lifestyle declines — they're enzyme shortages.
Mitochondrial Biogenesis Stops.
PGC-1α — the master switch that builds new mitochondria — depends on NAD+-activated SIRT1 to function. When NAD+ falls, PGC-1α stays inactive, and your body stops replacing damaged mitochondria. The energy infrastructure literally shrinks decade over decade.
Most NAD+ Supplements Don't Replace What's Lost.
You can't ingest NAD+ directly — it's too large to absorb. Most products use cheap nicotinamide that barely raises cellular NAD+. The clinically-validated route is NMN — but only at proper doses, with the methyl-donor support, and with the sirtuin activators that put NAD+ to work. Most products skip three of those.
A Discovery From The Sinclair Lab
The Precursor Molecule That Restored Cellular Function In Aged Mice — And Now Has Human Clinical Trials Behind It.
In 2013, a Harvard team led by Dr. David Sinclair published a paper showing that NMN supplementation in aged mice restored mitochondrial function to youthful levels within one week. Subsequent studies in humans (Yoshino 2021 in Science, Irie 2020) demonstrated metabolic improvements in postmenopausal women and healthy adults. Immortalis is built around NMN as the lead compound, with the cofactors required to convert it efficiently and put the resulting NAD+ to work.
BY THE NUMBERS
What 30 Years Of NAD+ Research Shows.
From the Sinclair lab to the published human trials — NMN is the most-studied longevity compound of the past decade.
The Honest Timeline
What you'll actually feel — week by week.
NMN raises NAD+ within days, but the downstream effects — sirtuin activation, mitochondrial biogenesis, metabolic flexibility — compound over weeks. Here's what to expect.
NAD+ rising under the surface.
Blood NAD+ levels begin rising within days of first dose. Most people feel nothing in this window — the cellular shifts haven't yet translated to subjective experience. Some users notice slightly deeper sleep by day 5-7. The biochemistry is repositioning before the subjective shift arrives.
Sleep deepens. Morning energy stabilizes.
By week 2, most users notice cleaner sleep architecture — fewer 3am wakeups, deeper deep-sleep, easier mornings. Daytime energy starts holding more consistently. The afternoon dip softens. Subtle but unmistakable shifts in how your day flows.
Sirtuin compound effects emerge.
Mitochondrial biogenesis builds with continued use. Metabolic flexibility improves — the body switches more efficiently between glucose and fat oxidation. Recovery from physical and cognitive demands gets faster. Some users notice improvements in skin quality, body composition, and exercise endurance in this window.
A new biological baseline.
Standard longevity protocols run NMN continuously. By month 2-3, the cumulative effects on mitochondrial density, sirtuin activity, and metabolic markers are most pronounced. This is when measurable shifts on bloodwork (insulin sensitivity, lipid panels, inflammatory markers) typically appear. The molecule isn't a feeling — it's a slow biological recalibration.
Why Conventional NAD+ Products Fail
Most "NAD+ Boosters" Don't Boost NAD+. Here's Why.
The supplement market has flooded with NAD+ products in the past five years. Most use the cheapest precursor, underdose it, skip the methyl donor, and ignore the sirtuin activators. Then they wonder why nobody feels anything.
Why Most NMN Products Are Underdosed
The Difference Between A Capsule That Works And A Capsule That's Marketing Theater Comes Down To Three Numbers.
Precursor form. Dose level. Cofactor inclusion. Most NMN products fail on at least two of these — and many fail on all three. Here's how the math actually plays out.
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Who Immortalis Is For — And Who It Isn't.
We'd rather lose your sale than have you on a longevity stack that interacts with a treatment plan you're already on.
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Build your longevity foundation
Immortalis is the upstream regulator. These compound the foundation.
Each adds a different vector to the longevity stack. Pick based on your reason for being on this page.
Methylene Blue Drops
Cellular energy pair · for direct mitochondrial rescue
Add if you want both upstream regulation (NAD+ / sirtuin) AND downstream rescue (electron transport bypass). Immortalis fuels the regulators; methylene blue rescues the machinery they regulate. Two complementary angles on the same cellular energy problem.
View Methylene Blue Drops →Ultimate Nattokinase
Cardiovascular pair · for vascular longevity
Add if you want to address fibrin accumulation and arterial flexibility alongside cellular aging. Cardiovascular health is the biggest single determinant of healthspan. Pairs with Immortalis for both cellular and circulatory longevity work.
View Ultimate Nattokinase →BPC-157 Capsules
Tissue repair pair · for active recovery
Add if you're rebuilding from injury, heavy training, or accumulated wear. BPC-157 handles tissue-level repair; Immortalis handles the cellular regulation that supports it. Foundational longevity stack.
View BPC-157 →Your Purchase Is Protected By A 60-Day Money-Back Guarantee.
Every Batch Lab Tested
Each batch is independently tested for identity, NMN purity, heavy metals, and microbial safety. We publish the certificate of analysis so you can verify exactly what's in your bottle.
60-Day Risk-Free Trial
Longevity compounds work over weeks to months. Give Immortalis 60 days of consistent use. If you don't notice a meaningful shift in energy, sleep, or metabolic baseline, contact us for a full, hassle-free refund.
Hassle-Free Refunds
No restocking fees. No long forms. No surveys. Email us, we process the refund. We'd rather lose the sale than have you on a stack that didn't deliver for your body.
It works. Hear from real people.
"Whoop scores started moving after 6 years stuck."
I've been tracking with Whoop for six years and my baseline hasn't shifted in any meaningful way despite cleaning up sleep, training, food. Three weeks of Immortalis and HRV started climbing. Six weeks in and my recovery scores are 15 points higher on average. Resting heart rate dropped four beats. Whatever it's doing, my watch agrees.
"Fasting glucose down 12 points. My endo was speechless."
Pre-diabetic for two years, A1C creeping up despite metformin. Six weeks on Immortalis and my fasting glucose dropped from 112 to 98. A1C followed a month later. My endocrinologist actually asked for the bottle to look at the label. Same diet, same exercise. The only thing that changed was this stack.
"Recovering like I did at 38."
Lifted heavy my whole life. By 55 the recovery between sessions was killing me — three days off felt mandatory. A year on this and I'm back to lifting four days a week without the soreness. I don't know if it's the NMN or the resveratrol or the whole stack, but something is working at the cellular level. Best supplement I've taken in 30 years.
"Sleep architecture rebuilt in three weeks."
Garmin showed me my deep sleep had been declining for two years. Three weeks of Immortalis and deep sleep is up 40 minutes a night, REM is up 25 minutes, and I'm waking up before my alarm. Energy throughout the day is just steadier. No spikes, no crashes. It feels like my baseline reset.
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Frequently asked questions
Both are NAD+ precursors with strong supporting evidence. NMN has slightly more direct human clinical trial data (Yoshino 2021 in Science being the most-cited). NR has its own substantial evidence base, including mitochondrial function studies. Both work. We use NMN because the published metabolic improvement studies in humans have used it specifically at our dose level.
NMN metabolism consumes methyl groups — specifically, it methylates nicotinamide produced as a byproduct, which can elevate homocysteine over time if methyl reserves run low. TMG (trimethylglycine) is a direct methyl donor that replenishes those reserves. It's the safety component most NMN products skip and the reason long-term Immortalis use stays metabolically clean.
Sleep quality often shifts first — typically within 2-3 weeks. Energy stability and afternoon dip improvement usually emerge by week 3-4. Metabolic markers (insulin sensitivity, lipid panels) take longer — typically 8-12 weeks of consistent use to show on bloodwork. Don't expect a stimulant kick. Expect a slow recalibration of how your day feels.
Most longevity researchers run NMN continuously without cycling. The TMG inclusion is what makes long-term continuous use sustainable — it prevents the methyl-depletion concerns that arise with NMN-alone protocols. Some users prefer 5 days on / 2 off; we don't think it's necessary, but it's a reasonable option.
Generally yes — Immortalis is designed as a foundational stack, not a single ingredient. It pairs well with rapamycin protocols, metformin (under physician supervision), and other longevity compounds. Take with or without food. If you're stacking with other resveratrol-containing products, account for total resveratrol intake to stay under 500 mg/day.
The published clinical trials run 8-24 weeks with no significant adverse events. The TMG inclusion mitigates the long-term methylation concerns that exist with NMN-alone protocols. Like any supplement, periodic bloodwork (annual at minimum) is a reasonable check-in. We're not aware of contraindications for healthy adults outside the audience exclusion list.
We offer a 60-day, no-questions-asked money-back guarantee. Use the bottle. If you don't notice a meaningful difference in energy, sleep, or metabolic baseline, email us with your order number and we'll refund you in full. No restocking fees, no surveys, no runaround.