Buy 3, get 2 free

Free US shipping over $75

60-day money-back guarantee

  • Buy 3, get 2 free
  • Free US shipping over $75
  • 60-day money-back guarantee
  • 10,000 FU per serving
  • Vitamin K2 removed
  • Third-party tested every batch
  • Ships from the USA
Ultimate Nattokinase bottle, front label

Healthy circulation.10,000 FU a day.

  • 10,000 FUPer serving
  • K2 removedNo added vitamin K2
  • 60-dayMoney-back guarantee
Third-party tested · every lot
Ultimate Nattokinase – bottle in hand
Ultimate Nattokinase – lifestyle and benefits
Ultimate Nattokinase – what to expect, week by week
Ultimate Nattokinase – the dose, side by side
Ultimate Nattokinase – versus the typical alternative
Ultimate Nattokinase – how to take: 2 capsules before breakfast
Ultimate Nattokinase – your first 90 days
Ultimate Nattokinase – what's inside: every dose on the label
Ultimate Nattokinase – lab tested: scan the label, see your batch
Ultimate Nattokinase – best value: buy 3, get 2 free
Ultimate Nattokinase – Supplement Facts
Ultimate Nattokinase – 60-day guarantee

Third-party tested · every lot

Ultimate Nattokinase – The 10,000 FU cardiovascular formula

500 mg of nattokinase (10,000 FU) from fermented natto, vitamin K2 removed, in a two-capsule daily serving.

  • Supports healthy blood flow and viscosity*
  • Supports arterial health*
  • Supports healthy fibrin balance*
  • Supports blood pressure already in the normal range*
  • Vitamin K2 removed
Choose your supply

Total $129$177

Save 27%No code needed

Free US shipping on this order · ships from the USA

  • 180-day supply$0.71 a day
  • 60-day guaranteeMoney back, no return
  • Third-party testedEvery lot

If it isn't for you within 60 days, email us and we refund you in full. No return needed. One-time purchase: no subscription, nothing renews.

Arrives with your order

  • ×3$129Ultimate Nattokinase
  • Free $39At 2 bottlesOG Hydro tablets
  • Free $39At 5 bottles2nd tube
  • FreeUS shipping

Pick 2+ bottles and a tube of OG Hydro hydrogen tablets ships free ($39 value).The 5-bottle pack adds a 2nd free tube ($39 value).Both tubes ship free with this pack ($78 value). You pick the flavors in the cart.

Sold only at upgradehealth.shop.

Unlike most brands, we name every ingredient and dose, and an independent lab tests every lot for identity, potency, heavy metals and microbial safety.

Ultimate Nattokinase third-party testing card

Certificates of analysis go online per lot from launch.

Ultimate Nattokinase3 bottles · $59.00/bottle

Your morning

Two capsules before breakfast. For healthy circulation.

  • Healthy blood flowSupports healthy blood flow and viscosity.
  • Fibrin balanceSupports your body's own fibrin clearing.
Ultimate Nattokinase bottle held in a hand
  • Arterial healthSupports flexible, healthy arteries.
  • Blood pressureSupports blood pressure already in the normal range.
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  • 10,000 FU

    nattokinase per two-capsule serving

    Supplement Facts panel

  • 4×

    enzyme activity vs. plasmin (lab study)

    Fujita et al. 1995

  • K2

    removed. Natto is naturally rich in vitamin K2; ours has it taken out

  • 1980

    year of discovery

    40+ years of published research since

The research

What the research shows. Close to the studied 10,800 FU a day.

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  • 10,000 FU nattokinase
  • Independent lab tested
  • K2 removed
  • No natto taste
A traditional Japanese breakfast of natto on rice with miso soup

Since 1980

From a fermented soybean. To 10,000 FU.

Made without vitamin K2.

Natto, sticky fermented soybeans, has been a Japanese breakfast for centuries. In 1980, Dr. Hiroyuki Sumi found the reason researchers took notice: an enzyme inside it, nattokinase, since studied for its role in fibrin balance.

A Japanese study that followed regular natto eaters for 16 years is one reason it is still researched today.

Most supplements sell 2,000 FU. We formulated at 10,000 FU per serving, and we removed vitamin K2.

Dose, side by side.

FU per serving
  • Generic cardio blend500 FU
  • Typical nattokinase brand2,000 FU
  • Extra-strength marketplace brand4,000 FU
  • Ultimate Nattokinase10,000 FU

What to expect

Week by week. No overnight promises.

This builds with daily use. Here's a realistic timeline.

  1. Weeks 1–2

    Settling in

    Two small capsules before breakfast. Most people feel little at first, and that's expected.

  2. Weeks 3–4

    Early signs

    Daily use supports healthy blood flow and viscosity.

  3. Weeks 5–8

    Building

    Pair it with a daily walk. Consistency matters most.

  4. Weeks 9–12+

    Your new baseline

    Circulatory support builds with consistent use. This is when most people decide to keep it in their routine.

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What's different

Why our nattokinase is built differently.

  1. Ultimate Nattokinase: A 10,000 FU serving

    Reason 1

    A 10,000 FU serving

    Nattokinase is measured in FU, a unit of enzyme activity. Most brands land around 2,000 FU a serving. Ours is 10,000.

  2. Ultimate Nattokinase: Vitamin K2 removed

    Reason 2

    Vitamin K2 removed

    Natto is naturally rich in vitamin K2. We remove it, so you get the enzyme without the K2.

  3. Ultimate Nattokinase: One enzyme, no blend

    Reason 3

    One enzyme, no blend

    Nattokinase in a vegetable capsule, with every other ingredient listed on the label. No proprietary blend.

  4. Ultimate Nattokinase: Every batch independently tested

    Reason 4

    Every batch independently tested

    FU potency, heavy metals and microbial safety, checked by an independent lab before a lot ships.

Compare

Ultimate Nattokinase vs a typical brand.

Same enzyme name on the front. Very different numbers on the back.

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60-day money-back guarantee

Ultimate Nattokinase

  • 10,000 FU per serving
  • Vitamin K2 removed
  • Every milligram on the label
  • Tested by an independent lab, every batch
  • Two small capsules, no natto taste

Typical nattokinase

  • About 2,000 FU per serving
  • K2 often left in
  • Doses sometimes hidden in a blend
  • Testing rarely published
  • Several capsules to reach a higher dose

How it works

How does nattokinase work?

Your body clears fibrin every day. Nattokinase supports that natural clearing system.

Ultimate Nattokinase directions card
Step 01 – BalanceSupports fibrin balance

Supports your body's normal, everyday fibrin turnover.

Step 02 – SupportSupports your own clearing system

Supports tissue plasminogen activator, the trigger for your body's own plasmin.

Step 03 – RelaxSupports flexible arteries

Supports the nitric-oxide pathway that lets arterial walls relax.

Fujita et al. 1995 · Kim et al. 2008

Compare

10,000 FU vs the usual 2,000.

A maintenance dose and the studied dose are not the same product.

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FeatureUltimate NattokinaseExtra-strength marketplace brandTypical nattokinase brandGeneric cardio blend
FU per serving10,000 FU4,000 FU2,000 FU500 FU
K2RemovedPresentPresentPresent
Third-partyEvery batchOccasionalRareNone

Comparison reflects typical products in each category. Formulas vary, so read any label before you buy.

Third-party tested

Made by us. Tested by an independent lab.

Ultimate Nattokinase is manufactured by UpGrade Health, Inc. and ships from the USA. Before a lot leaves us, an independent lab checks it.

  • Identity: the right ingredient, in the right form
  • Potency: the dose on the label is the dose in the capsule
  • Heavy metals and microbial safety
  • Certificate published per lot from launch
Try it risk-free

60-day money-back guarantee

Rows of Ultimate Nattokinase bottles

The guarantee

Give it 60 days. Keep it only if it earns its place.

Take it daily for 60 days. If it isn't for you, email us with your order number and we refund you in full. No return needed.

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60-day money-back guarantee

Start your 60 days.

Best value: 5 bottles, buy 3, get 2 free.

  • $35.40 a bottle, 40% off the single-bottle price
  • Free US shipping on orders over $75
  • 60-day money-back guarantee, no return needed

Or start with a single bottle for $59. . Same guarantee applies.

5 bottles

$177$295

Buy 3, get 2 free

Frequently asked questions.

I take medication. Is it okay?

Do not use if you take anticoagulant or antiplatelet medication (for example warfarin or apixaban) or have a bleeding or clotting disorder. Stop at least two weeks before scheduled surgery. Ask your doctor before use if you take any other medication.

Why 10,000 FU a serving?

Most nattokinase supplements land around 2,000 FU a serving. Ours is 10,000 FU, close to the 10,800 FU a day used in the largest published study. The amount is printed on the label.

Why is vitamin K2 removed?

Natto is naturally rich in vitamin K2, which is useful on its own. Removing it keeps the formula simple: the enzyme, without the K2. Removing K2 does not make this product suitable for anyone taking anticoagulant or antiplatelet medication. Do not use if you take them. If you want K2, take it separately with your doctor's guidance.

When will I notice anything?

Weeks 1–2: two small capsules before breakfast; most people feel little at first. Weeks 3–4: daily use supports healthy blood flow and viscosity. Weeks 5–8: pair it with a daily walk. Weeks 9–12+: circulatory support builds with consistent use. Consistency matters most.

What side effects should I know about?

Natto has been part of Japanese diets for centuries, and nattokinase was generally well tolerated in published studies. Do not use if you take anticoagulant or antiplatelet medication (for example warfarin or apixaban) or have a bleeding or clotting disorder. Stop at least two weeks before scheduled surgery. Ask your doctor before use if you take any other medication. Check with your healthcare professional first if you are pregnant or nursing.

Is it the same as eating natto?

Not quite. Natto is a whole food with a strong smell, a sticky texture and naturally high vitamin K2. Two capsules give you a standardized 10,000 FU of the enzyme with no taste, no smell and no K2.

What's the best way to take it?

Two capsules once a day, on an empty stomach about 30 minutes before breakfast. Same time each day. Keep up the movement, water and diet your doctor already recommends.

Warnings & directions

Directions
Take 2 capsules daily on an empty stomach, 30 minutes before a meal, or as directed by your healthcare professional.
Warnings
For use by healthy adults only. Keep out of reach of children. Not for use by individuals under 18. Do not exceed the suggested use. Do not use if you are taking anticoagulant or antiplatelet medication, or if you have a bleeding or clotting disorder. Discontinue use at least two weeks before any scheduled surgery. Consult your healthcare professional before use if you are pregnant, nursing, taking medication, or have a medical condition. Store in a cool, dry place. Do not use if safety seal is damaged or missing.
Allergens
Contains soy.
Made by
UpGrade Health, Inc. · Ships from the USA

Free gift$39value

OG Hydro Molecular Hydrogen Tablets, Strawberry Fizz

Strawberry Fizz

Free with 2+ bottles · from OG Hydro

Molecular HydrogenTablets

8 ppm of pure molecular hydrogen in a single 4 g drop-in tablet. Drop it in water, let it fizz, drink. No device, no charging, no waiting.

  • 8ppmMolecular hydrogen per tablet
  • 20Tablets per tube. Twenty drinks
  • 0gSugar, in every flavor
  • ~8minDrink within, for full potency
  1. Drop it inOne tablet into any glass or bottle of water.
  2. Let it fizzIt dissolves in about a minute.
  3. Drink upWithin about 8 minutes, before the hydrogen escapes.
  • Vegan
  • Zero sugar
  • No caffeine or stimulants
  • No artificial additives
  • Travel-ready

Molecular hydrogen (H₂) has been studied for its potential antioxidant effects, including as a selective antioxidant (Nature Medicine, 2007).*

How you get it

  • 2 bottles1 free tube$39 value
  • 5 bottles2 free tubes$78 value

Any mix of formulas counts. 3- and 5-bottle packs count as 3 and 5. The tubes go into your cart automatically, and you can pick the flavor of each one there.

Do not swallow the tablet directly. If you are nursing, pregnant, taking medication or have a medical condition, consult your physician before use. Keep out of reach of children. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.