BPC-157
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Healthy circulation.10,000 FU a day.
Third-party tested · every lot
500 mg of nattokinase (10,000 FU) from fermented natto, vitamin K2 removed, in a two-capsule daily serving.
Sold only at upgradehealth.shop.
Unlike most brands, we name every ingredient and dose, and an independent lab tests every lot for identity, potency, heavy metals and microbial safety.

Certificates of analysis go online per lot from launch.
Not in itVitamin K2 · Proprietary blend · Gelatin
Take 2 capsules daily on an empty stomach, 30 minutes before a meal, or as directed by your healthcare professional.
Do not use if you take anticoagulant or antiplatelet medication (for example warfarin or apixaban) or have a bleeding or clotting disorder. Stop at least two weeks before scheduled surgery. Ask your doctor before use if you take any other medication.
Most nattokinase supplements land around 2,000 FU a serving. Ours is 10,000 FU, close to the 10,800 FU a day used in the largest published study. The amount is printed on the label.
Natto is naturally rich in vitamin K2, which is useful on its own. Removing it keeps the formula simple: the enzyme, without the K2. Removing K2 does not make this product suitable for anyone taking anticoagulant or antiplatelet medication. Do not use if you take them. If you want K2, take it separately with your doctor's guidance.
Ships from the USA. Free US shipping on orders over $75. 60-day money-back guarantee: email us with your order number and we refund you in full, no return needed.

Your morning

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10,000 FU
nattokinase per two-capsule serving
Supplement Facts panel
4×
enzyme activity vs. plasmin (lab study)
Fujita et al. 1995
K2
removed. Natto is naturally rich in vitamin K2; ours has it taken out
1980
year of discovery
40+ years of published research since
The research
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Since 1980
Made without vitamin K2.
Natto, sticky fermented soybeans, has been a Japanese breakfast for centuries. In 1980, Dr. Hiroyuki Sumi found the reason researchers took notice: an enzyme inside it, nattokinase, since studied for its role in fibrin balance.
A Japanese study that followed regular natto eaters for 16 years is one reason it is still researched today.
Most supplements sell 2,000 FU. We formulated at 10,000 FU per serving, and we removed vitamin K2.
What to expect
This builds with daily use. Here's a realistic timeline.
Two small capsules before breakfast. Most people feel little at first, and that's expected.
Daily use supports healthy blood flow and viscosity.
Pair it with a daily walk. Consistency matters most.
Circulatory support builds with consistent use. This is when most people decide to keep it in their routine.
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What's different

Reason 1
Nattokinase is measured in FU, a unit of enzyme activity. Most brands land around 2,000 FU a serving. Ours is 10,000.

Reason 2
Natto is naturally rich in vitamin K2. We remove it, so you get the enzyme without the K2.

Reason 3
Nattokinase in a vegetable capsule, with every other ingredient listed on the label. No proprietary blend.

Reason 4
FU potency, heavy metals and microbial safety, checked by an independent lab before a lot ships.
Compare
Same enzyme name on the front. Very different numbers on the back.
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How it works
Your body clears fibrin every day. Nattokinase supports that natural clearing system.

Supports your body's normal, everyday fibrin turnover.
Supports tissue plasminogen activator, the trigger for your body's own plasmin.
Supports the nitric-oxide pathway that lets arterial walls relax.
Fujita et al. 1995 · Kim et al. 2008
Compare
A maintenance dose and the studied dose are not the same product.
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| Feature | Ultimate Nattokinase | Extra-strength marketplace brand | Typical nattokinase brand | Generic cardio blend |
|---|---|---|---|---|
| FU per serving | 10,000 FU | 4,000 FU | 2,000 FU | 500 FU |
| K2 | Removed | Present | Present | Present |
| Third-party | Every batch | Occasional | Rare | None |
Comparison reflects typical products in each category. Formulas vary, so read any label before you buy.
Third-party tested
Ultimate Nattokinase is manufactured by UpGrade Health, Inc. and ships from the USA. Before a lot leaves us, an independent lab checks it.
60-day money-back guarantee

The guarantee
Take it daily for 60 days. If it isn't for you, email us with your order number and we refund you in full. No return needed.
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Best value: 5 bottles, buy 3, get 2 free.
Or start with a single bottle for $59. . Same guarantee applies.
5 bottles
$177$295
Do not use if you take anticoagulant or antiplatelet medication (for example warfarin or apixaban) or have a bleeding or clotting disorder. Stop at least two weeks before scheduled surgery. Ask your doctor before use if you take any other medication.
Most nattokinase supplements land around 2,000 FU a serving. Ours is 10,000 FU, close to the 10,800 FU a day used in the largest published study. The amount is printed on the label.
Natto is naturally rich in vitamin K2, which is useful on its own. Removing it keeps the formula simple: the enzyme, without the K2. Removing K2 does not make this product suitable for anyone taking anticoagulant or antiplatelet medication. Do not use if you take them. If you want K2, take it separately with your doctor's guidance.
Weeks 1–2: two small capsules before breakfast; most people feel little at first. Weeks 3–4: daily use supports healthy blood flow and viscosity. Weeks 5–8: pair it with a daily walk. Weeks 9–12+: circulatory support builds with consistent use. Consistency matters most.
Natto has been part of Japanese diets for centuries, and nattokinase was generally well tolerated in published studies. Do not use if you take anticoagulant or antiplatelet medication (for example warfarin or apixaban) or have a bleeding or clotting disorder. Stop at least two weeks before scheduled surgery. Ask your doctor before use if you take any other medication. Check with your healthcare professional first if you are pregnant or nursing.
Not quite. Natto is a whole food with a strong smell, a sticky texture and naturally high vitamin K2. Two capsules give you a standardized 10,000 FU of the enzyme with no taste, no smell and no K2.
Two capsules once a day, on an empty stomach about 30 minutes before breakfast. Same time each day. Keep up the movement, water and diet your doctor already recommends.