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Glucose · Metabolism · Energy
METABOLIC+
Steadier after meals. The research dose, split in two.
500 mg berberine HCl and 100 mcg chromium in each two-capsule serving, taken with two meals a day — 1,000 mg berberine and 200 mcg chromium daily.
- Supports healthy glucose metabolism
- Supports blood sugar levels already within the normal range
- Supports healthy lipid levels already within the normal range
- Supports insulin sensitivity & metabolic health
Give it 60 days. If it isn't for you, email us and we refund you. Details
Lab report +
Every lot is tested by an independent lab for identity, potency, heavy metals and microbial safety. Look up your lot
METABOLIC+ by UpGrade Health is sold only on this site. We are not on Amazon, eBay, or any marketplace. If you see it elsewhere, it isn't ours.
Product details +
500 mg berberine HCl and 100 mcg chromium in each two-capsule serving, taken with two meals a day. 120 capsules.
Ingredients and warnings +
Read the full label and warnings below before use. Consult a healthcare professional if you take medication — especially for blood sugar — or have a medical condition.
Shipping and returns +
Ships from the USA. Free US shipping on orders over $75 and on every subscription. 60-day money-back guarantee — email us with your order number and we refund you in full, no return required.
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The research
What the research shows. 1,000 mg a day, across two meals.
- 36.9%of U.S. adults had optimal glucose levels in 2017–2018 — down from 59.4% in 1999–2000O'Hearn et al. 2022, n=55,081
- 1,000 mgberberine a day in a 3-month placebo-controlled trial of adults with glucose and lipids above the normal rangeZhang et al. 2008, n=116
- 12placebo-controlled trials pooled at 300–1,500 mg/day, with no significant difference in adverse events vs. placeboLiu et al. 2025, n=889
- <1%oral bioavailability of berberine — why the research splits the dose across mealsKhoshandam et al. 2022 (pharmacokinetic review)
Your lunch
Two capsules with a meal. Two more with the next.
Research dose
1,000 mg berberine a day.
Split with meals
Coverage for two meals, not one.
Chromium included
200 mcg a day, as picolinate.
No stimulants
Nothing to feel wired on.
Inside
Two actives. Every milligram shown.
- Glucose
Berberine HCl · 500 mg
From Berberis aristata. 1,000 mg a day across two meals.
- Insulin
Chromium · 100 mcg
As picolinate. May support the action of insulin.
- Stimulants
- Added sugar
- Gelatin
- Artificial colours
- Proprietary blends
How it works
Your cells sense energy. Berberine supports the signal.
Every mealSupports glucose uptake
Supports GLUT4 transporters moving to the muscle-cell surface.
Across the dayTwo meals, two servings
Berberine clears quickly, so the research split the dose across meals.
Over 12 weeksSupports lipid handling
Supports LDL-receptor expression in liver cells.
Sources: Lee et al. 2006 · Turner et al. 2008 · Kong et al. 2004 · NIH Office of Dietary Supplements (chromium)
What to expect
Week by week. No overnight promises.
Berberine is not a weight-loss shortcut — and anyone who tells you otherwise is selling hype.
-
Weeks 1–2
The foundation phase
Build the habit: two capsules with one meal, two with another. Always with food.
-
Weeks 3–4
First subtle shifts
Some people notice steadier afternoons, fewer post-lunch slumps, and more even energy between meals. Subtle, not dramatic.
-
Weeks 5–8
Momentum builds
Energy after meals feels more predictable. If you wear a glucose monitor, this is where many people start watching their after-meal curves more closely.
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Weeks 9–12+
The new normal
The human trials measured markers at around 12 weeks. That's the right time to recheck labs with your doctor.
Why it's different
Most berberine is taken once a day.
| METABOLIC+ | Typical berberine capsule | "Metabolism" gummy | |
|---|---|---|---|
| 1,000 mg berberine per day | Varies | No | |
| Split across two meals | Rarely | No | |
| Chromium included | No | Varies | |
| No added sugar | No | ||
| Purity tested every batch | Rarely | Rarely | |
| Every milligram on the label | Varies |
Comparison reflects typical products in each category. Formulas vary, so read any label before you buy.
Tested
Scan the label. See your batch.
Colour and raised gloss
Lab report lookup
The lot number is printed next to the QR code.
Certificates go online per lot from launch. Email us your lot number and we’ll send the report.
- Identity
- Potency
- Heavy metals
- Microbial
Every lot is tested by an independent lab. Certificates go online per lot from launch.
Give it 60 days. Keep it only if it earns its place.
No return needed. Email us and we refund you.
Best value
3 bottles. A 90-day supply.
- 3 bottles · $109.00
$147.00 - 60-day guarantee
- Free US shipping over $75
Questions people ask.
I take medication for diabetes, or a GLP-1 medication. Can I take METABOLIC+?
Talk to your doctor before you start — this is the most important answer on this page. Berberine may add to the glucose-lowering effect of insulin, metformin, sulfonylureas, GLP-1 medications, and other blood-sugar medications, which can push blood sugar too low. METABOLIC+ is not a substitute for any prescribed medication. Never stop or change a medication to take a supplement. If your doctor approves it, stop and call them if you notice signs of low blood sugar — shakiness, sweating, confusion, or a racing heart.
Can I take it with PCOS Support or another berberine product?
No. UpGrade PCOS Support also contains berberine, and so do many other "metabolic" and "glucose" products. Take one berberine product only — never double up. Check the labels of anything else you take.
Why 1,000 mg split across two meals?
1.0 g a day is the amount used in a 3-month, placebo-controlled trial of 116 adults, and it sits inside the 300–1,500 mg/day range pooled across 12 placebo-controlled trials. Berberine is poorly absorbed and doesn't linger, so the research divided the daily amount across meals. Two capsules with one meal, two with another.
You've probably seen berberine sold with a prescription-drug nickname. Is that what this is?
No. Berberine is a botanical, not a drug, and we don't market it with borrowed nicknames. What it is: the most-studied botanical for healthy glucose metabolism, at the dose used in human research. What it isn't: a weight-loss shortcut or a replacement for anything your doctor prescribed.
Why is there chromium in it?
Chromium is an essential trace mineral that the NIH notes may enhance the action of insulin. Honestly, research on chromium supplements by themselves is mixed. We include 200 mcg a day as a supporting nutrient alongside berberine — not as the reason to buy.
Is it safe? What about side effects?
The most common side effect is digestive — upset stomach or constipation. In a 3-month trial at 1,000 mg a day, five participants reported mild-to-moderate constipation; in a trial at 1,500 mg a day, about a third reported transient digestive effects. That's why METABOLIC+ is always taken with food. Do not use if you are pregnant, nursing, trying to conceive, under 18, or have liver disease. Talk to your doctor first if you take any medication — especially for blood sugar, blood pressure, blood thinning, or cyclosporine.
My blood sugar is already normal. Is this for me?
That's who it's built for. METABOLIC+ supports blood sugar levels already within the normal range and steady energy after meals. Most human studies were done in adults whose numbers were above the normal range, so we don't promise the same magnitude of change — and we won't pretend otherwise.
Warnings & Directions
- Directions
- Take 2 capsules with a meal, twice daily (4 capsules per day), or as directed by your healthcare professional. Do not exceed 4 capsules in 24 hours.
- Warnings
- Do not use if you are pregnant, nursing, or trying to conceive, or if you are under 18. Consult a healthcare professional before use if you take any medication — especially medication for blood sugar (including insulin, metformin, sulfonylureas, or GLP-1 medications), blood pressure, or blood thinning, or cyclosporine — or if you have liver disease or any medical condition. Discontinue use and consult your healthcare professional if you experience signs of low blood sugar. Do not combine with other berberine-containing products. May cause stomach upset; take with food. Do not use if the seal is damaged or missing. Keep out of reach of children. Store in a cool, dry place.
- Allergens
- None of the 9 major food allergens.
- Manufactured by
- UpGrade Health, Inc. · Ships from USA
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.